One of my colleagues, Chris Tierney, was installing a pristine copy of ColdFusion 11 on a Windows 2008 server. He followed our standard protocol which is to install the server using the "built in" Web server, then create instances (we typically use multi-server mode) then use wsconfig.exe to connect the instances to IIS. It all went as planned until he tried to run wsconfig.exe (FYI - you must always run this as administrator). He got an error as follows:
p\2\\ExecuteAppCmd\ExecuteAppCmd.exe": CreateProcess error=14001, The applicatio
n has failed to start because its side-by-side configuration is incorrect.
Followed by an odd stack trace. After experimenting with permissions and googling he stumbled on Bug 3761543 in the ColdFusion bugbase. The issue is not very well documented. Apparently the MS C++ package installed on 08 is 32 bit. I'm not clear if we installed it or it shipped with 08, but remember, you need the MS C++ 64bit SP1 Redistributable. Here's the download link from Microsoft so you don't have to hunt it down.
One more time: This download fixes the "side-by-side configuration" when installing ColdFusion 11 on Windows 2008r2.